The primary goal of this paper is to energize and mobilize an intensification of HIV prevention with an ultimate aim of universal access to HIV prevention and treatment. The paper defines the central actions that must be taken to arrest the spread of new HIV infections and to turn the tide against AIDS. It identifies what needs to be done to speedily and effectively bridge the HIV prevention gap, building on synergies between HIV prevention and care, and to ensure the sustainability of HIV treatment scale-up in the present context. It highlights the role of UNAIDS in relation to intensifying HIV prevention and points to ways in which jointly supportive action can be achieved. The largest investments in AIDS prevention targeted to the general population are being made in interventions where the evidence for large-scale impact is uncertain.